Search results for " Cyclic [administration & dosage]"
showing 10 items of 34 documents
Phosphasalen group IV metal complexes: synthesis, characterization and ring opening polymerization of lactide.
2020
International audience; We report the synthesis of a series of Zr and Ti complexes bearing phosphasalen which differs from salen by the incorporation of two P atoms in the ligand backbone. The reaction of phosphasalen proligands (1a-1c)H2 with Zr(CH2Ph)4 led to different products depending on the nature of the N,N-linker in the ligand. In case of ethylene-linked phosphasalen, octahedral Zr complex 2a formed as a single stereoisomer in trans geometry. With the phenylene linker, it was shown by dynamic NMR spectroscopy that complex 2b exists as a mixture of trans and cis-β isomers in solution, both enantiomers (Δ and Λ) of the cis-β isomer being in fast equilibrium with respect to the NMR tim…
Ionic Liquid Gels: Supramolecular Reaction Media for the Alcoholysis of Anhydrides.
2019
The search of new enantioselective catalysts, able to promote synthetically useful organic reactions with high levels of asymmetric induction, should be associated with the attention to the suitable reaction medium able to achieve the best efficiency in chemical processes. We have investigated the enantioselective desymmetrization of cyclic meso-anhydrides in nonconventional reaction media such as ionic liquids and supramolecular gels. With this aim, we examined several variables in the reacting system: the nature of ionic liquid used as the reaction medium, the gelation solvent, the structure of the anhydrides, the structure of alcohols, the chiral catalysts, and the reaction conditions, i…
Cannabinoid Control of Learning and Memory through HCN Channels
2016
The mechanisms underlying the effects of cannabinoids on cognitive processes are not understood. Here we show that cannabinoid type-1 receptors (CB1Rs) control hippocampal synaptic plasticity and spatial memory through the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that underlie the h-current (Ih), a key regulator of dendritic excitability. The CB1R-HCN pathway, involving c-Jun-N-terminal kinases (JNKs), nitric oxide synthase, and intracellular cGMP, exerts a tonic enhancement of Ih selectively in pyramidal cells located in the superficial portion of the CA1 pyramidal cell layer, whereas it is absent from deep-layer cells. Activation of the CB1R-HCN pathway impairs d…
HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond
2018
International audience; Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control neuronal excitability and their dysfunction has been linked to epileptogenesis but few individuals with neurological disorders related to variants altering HCN channels have been reported so far. In 2014, we described five individuals with epileptic encephalopathy due to de novo HCN1 variants. To delineate HCN1-related disorders and investigate genotype-phenotype correlations further, we assembled a cohort of 33 unpublished patients with novel pathogenic or likely pathogenic variants: 19 probands carrying 14 different de novo mutations and four families with dominantly inherited variants segre…
The role of extracellular calcium in bone metastasis
2016
AbstractThis review summarizes the role of extracellular calcium, as found present in the bone tissue, in the process of bone metastasis.
Continuous images of arcs: Extensions of Cornette's Theorem
2015
In [J.L. Cornette “Image of a Hausdorff arc” is cyclically extensible and reducible Trans. Am. Math. Soc., 199 (1974), pp. 253–267], Cornette proved that a locally connected Hausdorff continuum X is the continuous image of an arc if and only if each of its cyclic elements is the continuous image of an arc. Cyclic elements form a closed null cover of X by retracts of X. We generalize Cornette's result to closed null covers of X with a dendritic structure. We give examples to show that some of our conditions are necessary and we pose some open questions.
Dibutyryl cyclic AMP and adrenaline increase contractile force and 45Ca uptake in mammalian cardiac muscle
1973
The effects of dibutyryl cyclic AMP (DB-AMP; 10−3M) and adrenaline (2.2×10−6 M) on contractile force, 45Ca uptake, and total myocardial Ca concentration were investigated in electrically driven left auricles isolated from rat hearts. The experiments were performed at an extracellular Ca concentration of 0.45 mM and at low frequency of stimulation (15 beats/min). 45Ca exposure was 5 min. Under the conditions used, both drugs increased contractile force and enhanced 45Ca uptake (expressed as relative specific activity) by about 30% (DB-AMP) and 40% (adrenaline), respectively. Thus, the results provide evidence that the effects of adrenaline on 45Ca uptake in mammalian cardiac muscle can be mi…
Analisi Sperimentale del Comportamento Ciclico di Elementi in Calcestruzzo a Bassa Resistenza Confinati con FRCM
2013
Vengono riportati i principali risultati di una campagna sperimentale finalizzata alla caratterizzazione della risposta sotto carichi assiali ciclici di colonne di calcestruzzo a bassa resistenza con sezione circolare, quadrata e rettangolare, rinforzate con fibre di carbonio immerse in matrice cementizia (CFRCM). Sono state condotte prove di compressione assiale su 30 campioni di altezza 600 mm, 10 a sezione cilindrica di diametro 300 mm, 10 quadrata di lato 200 mm, e 10 rettangolare di lato 200x400 mm. Le prove sono finalizzate a indagare gli effetti del carico ciclico, della forma della sezione, del raggio di curvatura degli spigoli e del numero di strati di tessuto di rinforzo sul legam…
Musical pitch quantization as an eigenvalue problem
2020
How can discrete pitches and chords emerge from the continuum of sound? Using a quantum cognition model of tonal music, we prove that the associated Schrödinger equation in Fourier space is invariant under continuous pitch transpositions. However, this symmetry is broken in the case of transpositions of chords, entailing a discrete cyclic group as transposition symmetry. Our research relates quantum mechanics with music and is consistent with music theory and seminal insights by Hermann von Helmholtz.
Behavior in compression of concrete cylinders externally wrapped with basalt fibers
2015
Abstract This paper gives additional information on the use of new class of composites constituted by Basalt Fiber Reinforced Polymer (BFRP) bonded with epoxy resin to concrete specimens as an alternative confinement material for compressed concrete members with respect to carbon or glass fibers. From the experimental point of view, concrete cylinders are wrapped with continuous fibers, in the form of sheets, applying both full and partial discrete wrapping with BFRP straps, and then tested in compression. For comparison, few other concrete cylinders are wrapped with Carbon Fiber Reinforced Polymer (CFRP) sheets and tested in compression. The number and type of plies (full or partial wrappi…